Endocrine Abstracts

Glucocorticoid receptor (GR) is a ligand-dependent nuclear receptor which regulates the transcription of a wide spectrum of genes that are responsible for vital immunological, metabolic, developmental, and anti-inflammatory functions. GR transcriptional regulatory effects are modulated by co-regulators including the tetratricopeptide 5 (TTC5) which has been shown to stabilize GR and alter its action in response to cellular stress. TTC5 is a stress-responsive activator of p300 ...

Introduction: Acromegaly is associated with skeletal changes that are characterized by appositional bone growth, increased bone dimensions and increased bone turnover. PTH is an important regulator of bone remodeling and its anabolic action requires the presence of GH. The strong correlation found between PTH concentrations and bone turnover markers in active and treated acromegaly has led to the suggestion, that the effect of GH on bone turnover may be mediated by PTH. Succes...

Background: Although papillary thyroid carcinoma (PTC) is considered to have an excellent prognosis, some more aggressive variants have been identified that show reduced overall survival rates. Besides from the diffuse sclerosing, tall cell, columnar cell, and solid variant, the hobnail variant was newly recognized as one of these aggressive forms, affecting recurrence, metastasis, and overall survival rates.Methods: We performed a systematic review and ...

Objective: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk.<p class="...

Introduction: Women with non-metastatic breast cancer form a distinct subpopulation in which calcium homeostasis in response to treatment with denosumab has not been extensively investigated.Methods: Female patients with osteoporosis, who were eligible for treatment with denosumab, were prospectively enrolled (2011–2012) and divided into two groups; Group A consisting of patients with either no history or benign diseases non affecting bone metabolis...

Introduction Severe infection from the SARS-CoV-2 virus is associated with various manifestations, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may be related to fatalities. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is con...

Objective: Clinically apparent hypocalcaemia following total thyroidectomy occurs in 20–25% of patients subjected to total thyroidectomy, in 2-4% of these patients the hypocalcaemia is permanent. Treatment by per-os or iv administration of calcium supplements and vitamin D is suggested when the serum calcium concentration falls bellow a critical level, either before or whenever the patients develop clinical symptoms of tetany. The purpose of this study is to evaluate the ...

BackgroundPheochromocytomas (PHOEs) and paragangliomas (PGLs) are rare neuroendocrine tumors originating from chromaffin cells. PHEO/PGL incidence ranges between 2–8/million, with 10–49% of these tumors being detected incidentally during imaging performed for other reasons. Up to 40% of PHEOs/PGLs patients have disease-specific germline pathogenic variants. This study aimed to investigate the epidemiology, clinical course, and genetic backgroun...

Objectives: Triiodothyronine (LT3) administration for 48hours in patients undergone primary angioplasty showed favourable effects on cardiac function and remodelling early after myocardial infarction (Thy-Repair, EudraCT 2016-000631-40, Thyroid 2022 Jun;32(6):714-724). The present study investigated whether this beneficial effect was dependent on the severity of infarct size. The extent of infarct size is one of the main determinants of morbidity and mortality after myocardial...

Background: Obesity is associated with chronic low-grade inflammation that contributes to the development of metabolic syndrome (MS). Resistin, produced by neutrophils and monocytes, displays potent proinflammatory properties and has been associated with cardiometabolic disease. The aim of this study was to (a) determine serum resistin levels among obese patients with or without MS and (b) explore the role of the subsets of circulating white blood cells as potential determinan...